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Reactive oxygen species Adresse and apoptosis were analyzed using the suitable probes and flow cytometry. Consistent with the in vitro findings, the cartilage of the untreated OA-modeled rats harbored only a few Col II-positive chondrocytes in the superficial layers Fig. Steadman JR, et al. Although our findings are preliminary, they provide a novel anti-OA therapeutic strategy which needs to be validated further by clinical studies. For the sham-operated controls, a similar incision was made on the left hind limb but the ligaments were left intact. The Journal of rheumatology. Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis.

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Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Predictably, the inhibition of autophagy by 3-MA abrogated the restorative effects of PD in vitro. An increase in oxidative stress predisposes chondrocytes to a dysfunctional antioxidant response and apoptosis 28. Contributor Information Jia Li, Email: This study was designed to evaluate the therapeutic properties of PD in vitro and in vivoand elucidate their underlying mechanisms.

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View the profiles of people named Blake Alex. Join Facebook to connect with Blake Alex and others you may know. Facebook Sugar Grove, Illinois · Blake.

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